Background: Perimenopause is a time period before women has a final menses and later start with menopausal symptom that last up to 1 year after cessation of menses.[1,2] Perimenopause refer to the period around menopause (40–55 years). Aim and objective: The purpose of the study was to assess, using the menopausal rating scale, the efficacy of Oophorinum 30CH and Individualized Homeopathic medicine in treating perimenopausal complaints in the age range of 40 to 55 years. Material and methods: 46 cases were chosen in accordance with the inclusion criteria. The menopausal rating scale has been utilized to evaluate the improvement. Result: The unpaired t test was used to confirm the result. Conclusion: The study concluded that Individualized Homoeopathic medicine is more effective than Oophorinum 30 in reducing the intensity of perimenopausal complaints in 40-55 years of age.