Hypersomnia or Hypersomnolence is an inability to stay awake and alert during major waking episodes, resulting in periods of irrepressible need for sleep or unintended lapses into drowsiness or sleep. It is a neurobiological disorder where there is a disparity between sleep inducing and alertness promoting neurotransmitter which can be evaluated using ESS scale. Hypersomnia may impact on the day-to-day activities of an individual. Treating this disorder by conventional line of treatment may be expensive whereas, homoeopathic treatment might be cost-effective. This study shows the effectiveness of Nash Trio of sleepiness to manage the cases of Hypersomnia. • Objective: To study effectiveness of Nash trio of sleepiness in management of hypersomnia in the age group of 15 to 35 years. To identify the most commonly used homoeopathic medicine of Nash trio of sleepiness in our study. • Materials and method: This study includes a case series of 45 cases prescribed with Antimonium Tartaricum, Nux Moschata and Gelsemium i.e., the remedies of Nash trio of sleepiness on the basis of Leaders in homoeopathic therapeutics by E. B. Nash. The study was conducted in M(N)HMC opd, D. N. Patil High School and Jr. college and Siddeshwar Clinic, Malegaon. Paired T test was done to analyze the results statistically. • Result: Out of 45 cases, 88.89% showed improvement while 11.11% cases were not improved. • Conclusion: Nash Trio of sleepiness is effective in managing the cases of hypersomnia.