Vitiligo, the pigmentary disorder of indefinite cause is characterized by depigmented or hypo pigmented patches that result from absence or reduction in melanocytes .Vitiligo a disease of cosmetic problem but has much psychosocial impact. The success rate in treating this condition in conventional medicines is limited and sometimes, treatment follows with side effects. Efficacy of Homeopathic medicine in treatment of Vitiligo has fewer case records documented in the past. This is a case treated at Out Patient Department of Motiwala Homoeopathic Medical College and Hospital. The case was treated with Homoeopathic medicine silicea over a period of six months with steady improvement which is evident from the photographs and baseline scores arrived at by using Vitiligo Assessment Score Chart develop by CCRH, which was 16 at the entry and became Zero at the end of sixth month.