Objective: The aim of this study was the efficacy and utility of Natrum Mur with special emphasis in urticaria. Methods: Simple Randomized, single blind, study design had been adopted for the study in Hospital attached to Homoeopathic medical college, A total no. of 30 individuals of all age group, of both sexes and religions presented with signs and symptoms of Urticaria were included in the study. Accordingly the various outcomes were assessed by different attributes and variables. Result: The prevalence of Urticaria was found in all age group incidence but was quite high in young age group, where there was mental psycho-emotional suppression. Natrum Mur was found to be a Positive improvement with homoeopathic treatment in urticaria. Conclusion: Homoeopathic treatment is efficacious in the treatment of urticaria significantly.