Barrett’s esophagus is a complication of the gastro esophageal reflux disease. Gastro esophageal Reflux Disease (GERD) in which stomach acids are refluxed up through the esophagus and oral cavity, causing heartburn, chest pain, hoarseness, asthma, recurrent pneumonia, chronic cough, reflux laryngitis, and sore throat, and has different signs and symptom depending on the severity of the disease. Barrett’s esophagus is a pre-malignant condition that is diagnosed by endoscopy and biopsy. The current case report is about a 38-year-old female who was diagnosed with GERD resulting in Barrett’s esophagus. In this article, I given an account on this disease and cited a case treated homeopathically.