Toothache is very common clinical condition seen in dental OPD in day to day practice. Treatment of toothache depends upon the cause and severity. Root canal therapy is one of the procedures used to treat the toothache. Use of local anesthesia during the procedure has several side effects. Local anesthetics are frequently administered in dentistry and thus can be expected to be a major source of drug-related complications in the dental office. Additionally, the dentist will more often be confronted with the treatment of risk patients; thus, the incidence of side effects can be expected to rise. Complications associated with the administration of the local anesthesia of all patients, 45.9% had at least one risk factor in their medical histories, with cardiovascular diseases and allergies being the most frequent. Additionally, doses of local anesthetics proved not to be strictly determined according to body weight, especially for patients weighing less than 50 kg.[1] To prevent these side effects of local anesthesia, homoeopathic medicines can be used to subside the pain during process of Root Canal Therapy (RCT). In this study, we tried Coffea cruda 30 a homoeopathic medicine in the cases of RCT to reduce pain.