Hyperuricemia is a metabolic disorder in which serum uric acid level elevate above 7.0 mg/dl in men and 5.7 mg/dl in female. Hyperuricemia is results from increased uric acid production, decreased excretion, or a combination of both processes. This study was carried out with the objective to see the comparison between the effect of individualized Homeopathic medicine and colchicum autuamnale 30 in reducing the serum uric acid level .Materials and methods: - 46 patients with raised serum uric acid were selected on the basis on inclusion and exclusion criteria. Serum uric acid level was estimated before the study and at the end of 6th follow up. Result:-. According to Unpaired ‘t’ Test Null Hypothesis is accepted as calculated ‘t’ value 0.753621753 is smaller than table value 2.02 at 0.05 l.o.s. Unpaired ‘t’ test reflects that there is no difference in effectiveness of Colchicum autumnale 30 and Individualized Homoeopathic Medicine in cases of Hyperuricemia. Pair t test was applied for Group A whose calculated value is 13.0161995 l.o.s (table t value 2.07). This represents colchicum is effective in reducing Hyperuricemia. The most frequently prescribed Homoeopathic medicines were Natrum mur(5), Rhus tox(3), Bryonia alba(3) , Arsenic album(2) & Lycopodium(2). Maximum cases of Hyperuricemia were observed in females (57%) than males (43%).Conclusion:- Colchicum autumnale 30 and Individualized Homeopathic medicines are effective in reducing serum uric acid level along with associated symptoms.