Gout, a form of inflammatory arthritis, poses significant challenges in its management due to limited efficacy and adverse effects associated with conventional therapies. This study aimed to compare the effectiveness of Bacillus no.7, a probiotic agent, and individualized homeopathic medicine in the treatment of gout. A comparative interventional study was conducted on 46 patients diagnosed with gout, systematically assigned to two groups: Group A receiving individualized homeopathic medicine , Group B receiving Bacillus no. 7. ACR EULAR Criteria was utililized for screening the potential patients of gout.The primary outcome measures serum uric acid levels, assessed at baseline and follow-up visits over a period of 6 months. Secondary outcomes encompassed reduction in intensity of pain (using NPRS). Statistical analysis revealed significant improvements in pain intensity and serum uric acid levels in both intervention groups. However, significant difference was observed between Bacillus no.7 and individualized homeopathic medicine groups in terms of efficacy. Furthermore, both interventions demonstrated a favorable safety profile with minimal adverse effects. Overall, our findings suggests that individualized homeopathic medicine may offer promising alternative therapeutic options for managing gout as compared to Bacillus no.7, warranting further investigation into their mechanisms of action and long-term effects.[1][4]