Migraine is a neurological disease which usually causes a pulsating, throbbing headache on one side of the head. The pain may be extremely bad and hurt so much that a person may have a hard time following his routine. Not every person who is diagnosed with migrane suffers with headache. There are different kinds of migraines, and some do not cause a headache but do have symptoms. Most migraines cause headache and nausea and might make the person dizzy or very sensitive to bright lights or loud noises. Some people have "auras" before a migraine starts, which means their vision becomes different. Patients may see funny patterns, have blurry vision, or may not be able to see at all. Other senses can change before or during a migraine, and the patient may sense funny smells or tastes. Migraines can last for a long time. Migraines usually last between four and 72 hours. Modern medicine doesn’t know the cause of onset of this disorder hence cannot figure out a curative treatment for the same. Objectives: To improve the quality of life of patients suffering from migraine after homoeopathic prescription and to study the efficacy of homoeopathic medicines in cases of migraine. Materials and methods: The study is a case series was carried out in 45 patients within the age group of 15 to 60 years suffering from migraine fitting the inclusion criteria were prescribed individualized homoeopathic medicines for migraine and followed for a period of 6 months. The outcome assessment was done by scores before and after treatment. Result: At the end of the study it was observed that out of 45 patients, 37 patients improved (82%). The average age of the patients taken into consideration was 28.9 which is mostly the age where people are at their peak of career and need to be as productive as possible. Migraine limits their productivity to a great extent, usually more than 50%. Out of the 45 cases studied, only 12 were males (27%) and 33 patients were females (73%), hence the prevalence was more in females than males. The commonest used medicines were Natrum mur, Ignitia, Pulsatilla, Nux vomica and Arsenic album. Conclusion: There is a broad scope of homoeopathy in the treatment of migraine in improvement of quality of life by reducing the intensity, duration, and frequency of episodes.