Vaccination is the method in which microbes are introduced into the human body that is live or killed and its acts like stimulating immune response and protect the children’s from infectious agents. After the administration of any vaccine, ill effect of vaccine mostly we found. That time we need to prescribe on the basis of acute totality in the acute complication. Constitutional medicine is depending on the physical generals, mental generals and particulars in the chronic complications which are developed after vaccination. Aim of this study is to find out the effect of homoeopathic medicine in the post vaccination syndrome in pediatrics age group. Vaccine causes the adverse effect of vaccination so, to knowing all this thing, the primary objective of this study is to find out the effect of homoeopathic medicine in the post vaccination syndrome. Secondary objective for this study is to find out the specific group of homoeopathic medicine which acts on the post vaccination syndrome. Methods – Simple randomized sampling method with 30 cases in which patients were enrolled till the target was achieved. The patients were selected on the basis of inclusion and exclusion criteria. Patient was considered on the basis of clinical presentation. Prescription of each case was based on the Individualized prescription. Outcome was assessed to measure the reduction in the intensity of the sign and symptoms. Result -All 30 cases were studied after administration of homoeopathic remedy in post vaccination syndrome. Out of 30 cases 27 cases showed improved and 3 cases showed not improved. Study of post vaccination syndrome seen after administration of following vaccines 7 MMR vaccine, 5 Pentavalent vaccine, 8 DPT & OPV vaccine, 4 Hepatitis B vaccine, 2 Typhoid vaccine, 2 JE & Vitamin A vaccine, 1 VAR, 1 IPV vaccine cases. No any specific group of homoeopathic medicine were observed but in this study ThujaOccidentalis, Sulphur, Silicea, and Antim tart were frequently prescribed medicine. Conclusion - This study provides that there is evidence to say that homoeopathic medicine is effective in treating the post vaccination syndrome.