We are quite familiar with the prescription on the basis of Causation. Although, this kind of prescription is strongly supported by a number of cases successfully treated so far, we should not be blind in considering causation. It should be noted that, in some cases, the causation could either be a coincidence or a misconception. Hence always weigh its credibility before you consider. Introduction: Among various systems of medicine, Homoeopathy gives great importance to causation. Causation is one of the elements of symptoms, which when strong and genuine, is of much benefit in the remedial diagnosis, and so far we have come across several successful cures made by remedies selected on this basis. In the field of medicine, the word “Cause” has been used since ages. Physicians knew that there can not be diseases without a cause. Every great discovery and achievements are the result of the curiosity behind the question ‘’WHY’’? [The Cause]. “No smoke could be there without fire” is an old proverb. Among the physicians of orthodox system, the concept of “Tolle causam” (remove the cause) was prevalent. They believed that by removing the cause of a disease, it could be cured. But later they made the mistake by proposing that bacteria are the only cause behind diseases and by removing the bacteria a cure could be attained. But homoeopathy goes further and propagates that there is a cause in the dynamic level that comes to activity much before the invasion of microbes. This dynamic cause should be removed to cure a patient. As per the concept of homoeopathy, thecause behind every disease is derangement of the vital force by the dynamic noxious influences called miasms. This is the real cause that flows into effect in the form of sickness. Hence, tolle causam can be related with both orthodox medicine and homoeopathy, but for the former it is about removing the material cause and for the latter it is the removal of a dynamic cause.