Background: Addiction is a chronic relapsing condition marked by obsessive drug seeking and use despite negative effects.(1) The use of tobacco increases the chance of developing several chronic diseases, including cancer, lung disease, cardiovascular disease, and stroke. Aim: To study the efficacy of Plantago Major Mother Tincture in tobacco de-addiction in age group above 15 years including both male and female. Objectives: Primary objective: To study the efficacy of Plantago Major Mother Tincture in tobacco de-addiction. Secondary objective: To study the tobacco (Nicotine) dependency by using Fagerstrom Nicotine Dependence Scale after administration of plantago major mother tincture. (14) Materials and Methods: Case series study was done among 30 subjects with Tobacco addiction randomly selected from M (N)HMC OPD and peripheral camps. Status of addiction of subjects was measured with Fagerstrom Nicotine Dependence scale. Plantago major mother tincture was administered. Result: Statistical analysis was done using Paired t test. Out of 30 patients, efficacy of plantago major Ø is seen in 24 patients (80%) and frequency & dependency remains same in 6 patients (20%). Conclusion: According to statistics of nicotine addiction calculated before and after intervention of plantago major Ø for dependency gives the t value of 7. Hence, we concluded that Plantago Major Mother Tincture is effective in management of Tobacco de-addiction.