Background:Post traumatic stress disorder (PTSD) is a debilitating mental health condition that can develop in individuals who have experienced or witnessed traumatic events, such as road traffic accidents (RTAs). This research article explores the significant role of homeopathy in the management and treatment of PTSD among RTA survivors. PTSD is characterized by a complex interplay of symptoms, including intrusive thoughts, nightmares, hyperarousal, and emotional numbing, often leading to impaired functioning and a diminished quality of life. Objectives: 1st objective was to evaluate the role of homoeopathic medicines in treating the cases of post traumatic stress disorder in road traffic accident survivors and 2nd objective was to find out the most commonest indicated homoeopathic medicines in treating cases of PTSD in RTA survivors. Methods: This was an experimental, nonrandomized, uncontrolled study which was carried out on the participants who have been diagnosed with PTSD after RTA. A structured questionnaire regarding symptoms of PTSD was filled out by participants. Participants of any gender and of any age were included and participants with grave pathology and suffering from any mental disease were excluded. Paired t-test was applied to measure the PTSD checklist for DSM-5 (PCL-5) with Life Events Checklist for DSM-5 (lec-5) and Criteria A Part 3 scale score. Results: 50 participants took part in the study. 94% (n=47) showed improvement and 6% (n=3) showed no improvement. 94%(n=47) participants noticed considerable changes in their health condition after taking homoeopathy and after following advice given to them and 6% (n=3) didn’t notice any change. After applying the paired t-test the calculated t value came to be as 12.97 which is greater than table t-value that came as 2.01 and the two tailed p value came less than 0.0001, by conventional criteria, this difference is considered to be extremely significant. Conclusion: According to above result we conclude that Homoeopathic Medicines in Post Traumatic Stress Disorder (PTSD) in Road Traffic Accident (RTA) Survivors are Effective.