Myeloproliferative disorders (MPD) are types of blood cancer caused by changes in the stem cells in which number of red blood cells, white blood cells and platelets increases abnormally in the bone marrow. Current treatments are Allogeneic Stem Cell Transplantation, targeted drugs, chemotherapy and immunotherapy. This is a case of a lady, 54years old presented at Astha Homoeopathic Clinic with complaints of numbness, heaviness, tenderness and dull aching pain at left hypochondriac region. Investigations showed massive enlargement of spleen up to 20.5cm and multiple enlargements of lymph nodes suspected as Myeloproliferative disorder (Chronic myeloid leukaemia). There was also hepatomegaly and dilated portal vein(1.5cm). The patient was interviewed in detail according to Hahnemannian Homoeo Forum [HHF] method where emphasis was given on the personality, the concern, adaptation and psychodynamic understanding of the disease to select the similimum. The homoeopathic treatment resulted in gradual resolution of the enlarged spleen from 20.5cm to 11.3cm. Hepatomegaly was resolved. Enlarged pre and para aortocaval lymph nodes also regressed after 3-4 months. The case demonstrated effectiveness of standardised homoeopathic treatment selected on the basis of individuality in order to restore health with good quality of life in rapid and gentle way even in the grave pathology.