Background: Motion sickness is an ill feeling, a common problem in people traveling by car, boat, train, and plane or while on amusement rides. Motion sickness can be triggered by rocking in a boat, air turbulence in an airplane, being in the back seat of a car unable to see the horizon, reading in the car. Objectives: To study the comparative efficacy of cocculus indicus and homoeopathic indicated medicine in motion sickness, in the age group between 10-55 years. To find out the most commonly Homoeopathic Indicated Medicine. Material and Method: A thorough case-taking process, guided by the homeopathic principle, comparative study was done. Patients recruited were assessed as per the MSAQ scale and Homoeopathic medicines were prescribed based on the law of simila. Regular assessments, follow-up, and statistical analysis using t-tests. (paired and unpaired).Result: The results show that there is difference in effectiveness of Cocculus Indicus & Homeopathic Indicated Medicine in cases of Motion Sickness so, our alternative hypothesis was accepted. We rejected the null hypothesis at 5% I.O.S.since calculated value of t(4.56) is greater than table value of t(2.07).Conclusion: The study found that homoeopathic indicated medicine shown more improvement in the cases of motion sickness than the cocculus indicus based on the MSAQ(Motion Sickness Assessment Questionnaire).