Causation plays a major role behind every disease. The cause and its corresponding effect combine with the individuality of the patient helps to form the totality. The Aim and objectiveswas to study the utility of rubric “Ailments from” using Synthesis Repertory 10.0 (RADAR) and its application in Homoeopathic case management, to study the rubrics and sub- rubrics of “Ailments from” through cases with Synthesis Repertory 10.0 and to classify the rubric “Ailments from” in terms of symptomatology. In this study synthesis repertory is used by applying the knowledge of reportorial totality and using the Ailment factor of the illness for treating the case to make the prescription in Homeopathy more substantial. Theneedforthis studywas tofacilitate aclear understandingand importanceof therubric“Ailments from” in clinical practice. Methods: Simple random technique of sampling with 30 cases in which the patient was enrolled till the target of 30 cases was achieved. The cases were selected onbasis of inclusion and exclusion criteria. All cases were taken as per the case record format prepared for the study. Cases was collected from the CollegeOPD, Guide OPD, Peripheral OPD. Constructing the totality of symptoms andrepertorization was done for each case by using RADAR Synthesis repertory 10.0. Prescription of each case was based on the rubric “Ailments from” of the individual case. Changes in symptoms and clinical presentation were the parameters for assessing cases as marked improvement, improving and not improved. Results: Out of 30 cases, 21 cases showed marked improvement, 8 cases were improving and 1 case was not improved. Conclusion: This study provides evidence to say that the rubric “Ailments from” from RADAR Synthesis repertory 10.0 is useful as a characteristic symptom in homoeopathic case management.