Premenstrual syndrome is a group of symptoms which is physical, psychological and behavioural. The exact cause and etiology is unknown but it seems to related to ovarian function and other endocrinal factors. The severity of symptoms varies from female to female and it depends on individuality of the female. Some female may experience such severity that may disturb their daily activities and seeking for medication so we want to know the homoeopathic approach in PREMENSTRUAL SYNDROME .A case of premenstrual syndrome of a female treated with homoeopathy is reported here. This case shows the usefulness of homoeopathic remedy Folliculinum.