Cold-related illnesses pose significant health challenges, particularly affecting the respiratory, cardiovascular, and musculoskeletal systems. Exposure to cold leads to bronchoconstriction, vasoconstriction, and immune suppression, increasing susceptibility to respiratory infections, cardiovascular diseases, and rheumatic conditions. Conventional treatments provide symptomatic relief, whereas homeopathy offers a holistic approach, addressing both the exciting cause (cold exposure) and constitutional susceptibility of individuals. This systematic review explores the pathophysiology of cold-related illnesses, their classification under the International Classification of Diseases (ICD), and homeopathic therapeutic strategies. Key remedies such as Aconitum Napellus, Rhus Toxicodendron, Dulcamara, and Gelsemium are frequently indicated based on repertorial data. The review also highlights the role of exciting causes in homeopathic case-taking, repertorial rubrics related to cold exposure, and Materia Medica references. Despite its clinical application, homeopathic treatment of cold-related illnesses lacks large-scale, systematic validation. Most studies are case-based rather than randomized controlled trials (RCTs), underscoring the need for standardized trials with well-defined protocols. Future research should focus on RCTs comparing homeopathy with conventional treatments, developing clinical guidelines, and investigating the molecular mechanisms of homeopathic dilutions in cold-induced conditions. This study aims to contribute to evidence-based homeopathic practice for managing cold-related illnesses.