Background: GERD is a common health problem which many times remain undetected due to free and wide spread use of PPIs & sometimes patient may diagnose the complaint by themselves and they avoid to go to clinics unless they cause discomfort. But the GERD can be very well treated with homeopathic remedies without any complications. It commonly affects the quality of life of patient. Aim and Objective : To Study the difference between Indicated Homoeopathic Medicine and Indicated Homoeopathic Medicine Along with Natrum Phosphoricum 6X in cases of Gastroesophageal reflux Disease. Materials and Methods: The study is a Comparative , where 30 Patients are divided into 2 Groupson the basis of inclusion , exclusion criteria and FSSG Scale . In Group A- Homoeopathic Indicated Medicine were prescribed , and in Group B – Homoeopathic Indicated Medicine Along With Natrum Phos 6X were prescribed for GERD . Results : There is no statistical significant difference between effect of Indicated Homoeopathic Medicine and Indicated Homoeopathic medicine along with Natrum Phosphoricum 6X in cases of GastroesophagealRefulx Disease. Because its is observed that in Group A : Biochemic + Indicated homeopathic group out of 15 patients , 14 patients have shown changes / improvement, on other hand in Group B: Indicated homoeopathic group all 15 patients have shown improvement. Conclusion : We Conclude for our study that there is no difference between Indicated Homeopathic medicine & Indicated Homeopathic medicine with Natrum Phos 6X in management of GERD.