Dr. Hahnemann is the first person who made the relation between disease & medicine similarity by conceiving and utilizing it to form new therapeutic system in field of Medicine. Dr. Hahnemann has confirmed the law of Cure, not only with pure experiments but also by keen observations . This article’s objective is to emphasis on the evolution of the law of Similia. The objectives were to study the evolution of the law of Similia and to trace roots of it in past. The method by evidence-based study of Dr. Hahnemann on the law of Similia and also some of the other stalwarts and their schools (pathy).