Psoriasis is a common, chronic and non-infectious skin disease characterized by well defined slightly raised, dry erythematous macules with silvery scales and typical extensor distribution. Objective: The effect of homoeopathic treatment in cases of psoriasis studied in age group 10-60 for 6 months. Prevalence of psoriasis in both males and females. Design: A Retrospective observational study. Psoriasis Area Severity Index scale (PASI) were used for evaluating cases. Material and method: 45 patients were selected for the present study on the basis of clinical sign and symptoms of psoriasis. To assess the cases improvement psoriasis area severity index scale were applied. The study include patient taking treatment from 2018.Result: Homeopathic medicine were found to reduce the PASI score in patient. Conclusion: Hence, homoeopathic medicine is effective in psoriasis when studied in age group 10- 60 in both sexes. Out of 45 cases 91% cases are improving, 6.66% cases are not improved and 2.2% cases are improved.