Muscular dystrophies are group of genetic diseases of muscles. The commonest is Duchenne’s muscular dystrophy, prevalence been 1:3500 live male births. Disease manifests at approximately 4years of age with the symptoms like clumsy walking, difficulty in standing, and respiratory failure. Life expectancy is about 20years [1]. There is no specific treatment for curing this disease. Homoeopathy, however, provides a better response in such conditions; one such case report is been presented below. Patient attended outpatient department (OPD) chiefly for complaints of weakness of both the lower limbs, difficulty in walking & falling down frequently. Complaints had increased since last 1 year. Occasionally patient experienced pain in both lower limbs. Dissatisfied with the outcome after taking treatment with modern medicine, patient turned to homoeopathic treatment. After detailed case-taking and repertorization ,he recieved Cina 200 followed by Rhus Tox 200 and Rhus Tox 1M.Along with homoeopathic medicines patient continued with physiotherapy and naturopathy. Within two months of treatment, the patient showed significant improvement in his symptoms and biochemical parameters.