Our lifestyle has become very busy today. As a result, more and more people are exhibiting symptoms of stress and anxiety in general and college students are known to experience massive amounts of stress in particular. Studies shows that India has one of the highest rates of suicide between ages of 15 to 29. Thus the magnitude of problem today's world is serious, which made us to think over it. This study aims at helping the medical student to overcome their stress level with the help of homoeopathic medicines and relaxation techniques like meditation. Objective: To compare the effect of homoeopathic medicine versus placebo in reduction of stress level in medicalstudents receiving meditation. Materials and Methods: A randomize control trial was conducted at Motiwala homoeopathic medical college and hospital, Nashik Standard process stress assess scale was used to measure stress level before and after treatment.48 students were recruited for the study. Randomization was done and study group received Homoeopathic medicine and control group was given placebo. Both the groups received meditation together simultaneously. Improvement was recorded after 4 months of treatment. Result: The mean score before and after in study group were 70.37 and 53.30 and in control group 69.33 and 54.66 respectively. Conclusion: The study concludes that the Homeopathic medicines when used along with Meditation will effectively reduces the stress levels in medical students as compared to placebo combined with meditation.