Hepatitis B is systemic infection caused by hepatitis B virus with major pathology caused in liver and transmitted usually by parenteral route1. Spectrum of disease asymptomatic antigenemia chronic hepatitis, cirrhosis, hepato cellular cancer; early phase often associated with continued symptoms of hepatitis, elaveted aminotransferase levels, presence in serum of HBe Ag and HBV DNA, and presence in liver of replicative form of HBV, later phase in some of patients may be associated with clinical and biochemical improvement, disappearance of HBe ag and HBV DNA and appearance of anti-HBe Ag in serum, and integration of HBV DNA into host hepatocyte genome2. In convetional line of treatment the cost for management is upto 3-4 lacs per annum but it is not affordable for everyone. A pilot case study was conducted in Motiwala homoeopathic medical college OPD, with the objective to reduce the viral load with homoeopathic medicine and also to study cost effectiveness of homoeopathic management in hepatitis B infection. The case was treated with Lachesis, a homoeopathic medicine reported here. This case shows the efficacy of medicine in both subjective and objective parameters without conventional medicine intervention. Materials and methods: A case is taken from homeopathic medical college OPD and prescribed on basis of totality of symptom according to law of similia. Result: In a period of 1 year the viral load of patient decreased from 1, 65, 00,000 to 4, 39, 372. Total cost expenditure over 1 year was 130 Rs. (INR). Homeopathic Medicine is the cost effective management for reduction of viral load in Hepatitis B infection. Conclusion: Homeopathic Medicine is the cost effective management for reduction of viral load in Hepatitis B infection.